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Animals. From a nucleus of random-bred Sprague-Dawley
rats received in June 1960 from the Animal Production Unit,
National Institutes of Health, a colony of rats has been raised
in our laboratory by brother-to-sister mating...
Irradiation of Partially Shielded Rats. In a small series of
experiments, Sprague-Dawley rats, about 3-4.5 weeks old,
whose tails and both hind extremities were shielded by a lead
tube inserted as far as possible up to the inguinal area, received
one or two consecutive irradiations of 250 rads each, or four
consecutive irradiations of 150 rads each, at weekly intervals.
RESULTS
Incidence and Forms of Spontaneous Tumors and Leukemia
in our Colonies of Sprague-Dawley and Long-Evans
Rats. Table 1 shows that, among 133 Sprague-Dawley females,
we have observed 29 tumors and 5 leukemias. Among 141
males, only 7 developed tumors and 2 developed leukemia. The
incidence of tumors was higher in the Long-Evans rats; among
181 females 51 developed tumors and 5 developed leukemia;
among 179 males, only 18 developed tumors but 9 developed
leukemia.
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